کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2094429 1082019 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Toward a Rosetta stone for the stem cell genome: Stochastic gene expression, network architecture, and external influences
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Toward a Rosetta stone for the stem cell genome: Stochastic gene expression, network architecture, and external influences
چکیده انگلیسی

We review literature relating to three types of factors known to influence stem cell behavior. These factors are stochastic gene expression, regulatory network architecture, and the influence of external signals, such as those emanating from the niche. Although these factors are considered separately, their shared evolutionary history necessitates integration. Stochastic gene expression pervades network components; network architecture controls, modulates, or exploits this noise while performing additional computation; and such complexity also interplays with factors external to cells. Adequate understanding of each of these components, and how they interact, will lead to a conceptual model of the stem cell regulatory system that can be used to drive hypothesis-driven research and facilitate interpretation of experimental data.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Stem Cell Research - Volume 1, Issue 3, September 2008, Pages 157–168
نویسندگان
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