کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2094477 1082022 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The epicardium signals the way towards heart regeneration
ترجمه فارسی عنوان
اپیکاردی مسیر راه بازگشت به قلب را نشان می دهد
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


• The epicardium is a dynamic signalling centre during heart development and injury.
• Heart repair in lower vertebrates highlights the importance of epicardial signalling.
• Epicardial signals may be targeted to regenerate adult mammalian hearts.

From historical studies of developing chick hearts to recent advances in regenerative injury models, the epicardium has arisen as a key player in heart genesis and repair. The epicardium provides paracrine signals to nurture growth of the developing heart from mid-gestation, and epicardium-derived cells act as progenitors of numerous cardiac cell types. Interference with either process is terminal for heart development and embryogenesis. In adulthood, the dormant epicardium reinstates an embryonic gene programme in response to injury. Furthermore, injury-induced epicardial signalling is essential for heart regeneration in zebrafish. Given these critical roles in development, injury response and heart regeneration, the application of epicardial signals following adult heart injury could offer therapeutic strategies for the treatment of ischaemic heart disease and heart failure.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Stem Cell Research - Volume 13, Issue 3, Part B, November 2014, Pages 683–692
نویسندگان
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