کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2094479 1082022 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation
ترجمه فارسی عنوان
ماکروفاژ ها در هوموستاز قلبی، پاسخ های آسیب و بسیج سلول های پیش داوری
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


• Macrophages have diverse roles in uninjured and injured hearts.
• Recent findings indicate that macrophages can regulate stem cell activity.
• We propose that macrophages regulate cardiac progenitor cells particularly after injury.

Macrophages are an immune cell type found in every organ of the body. Classically, macrophages are recognised as housekeeping cells involved in the detection of foreign antigens and danger signatures, and the clearance of tissue debris. However, macrophages are increasingly recognised as a highly versatile cell type with a diverse range of functions that are important for tissue homeostasis and injury responses. Recent research findings suggest that macrophages contribute to tissue regeneration and may play a role in the activation and mobilisation of stem cells. This review describes recent advances in our understanding of the role played by macrophages in cardiac tissue maintenance and repair following injury. We examine the involvement of exogenous and resident tissue macrophages in cardiac inflammatory responses and their potential activity in regulating cardiac regeneration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Stem Cell Research - Volume 13, Issue 3, Part B, November 2014, Pages 705–714
نویسندگان
, , ,