کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2101833 1546263 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High Diagnostic Yield of Dedicated Pulmonary Screening before Hematopoietic Cell Transplantation in Children
ترجمه فارسی عنوان
عملکرد تشخیصی بالا بردن غربالگری اختصاصی ریوی قبل از پیوند سلول های هماتوپوئیدی در کودکان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• Pulmonary screening before hematopoietic cell transplantation reveals important abnormalities.
• Testing for lung function, structure, and microbial colonization contribute separately.
• Therapeutic implications of different findings are described.

Pulmonary complications are an important cause for treatment-related morbidity and mortality in hematopoietic cell transplantation (HCT) in children. The aim of this study was to investigate the yield of our pre-HCT pulmonary screening program. We also describe our management guidelines based on these findings and correlate them with symptomatic lung injury after HCT. Since 2008, all patients undergo a dedicated pulmonary screening consisting of pulmonary function test (PFT), chest high-resolution computed tomography (HRCT), and bronchial alveolar lavage (BAL) before HCT. We systematically evaluated the yield during the first 5 years of our screening program. We included 142 consecutive children. In 74% of patients, abnormalities were found. In 66% of patients, 1 or more PFT results were <80% of normal. Chest HRCT showed abnormalities in 55%; 19% of these abnormalities were considered “clinically significant.” BAL was abnormal in 43% of patients; respiratory viruses (PCR) were found in 35 patients, fungi (antigen or culture) in 21, and bacteria (culture) in 22. All 3 screening tests contributed separately to clinically relevant information regarding pulmonary status in these pre-HCT children. In 46 patients (33%), screening results had diagnostic and/or therapeutic implications. We found an association between pre-SCT HRCT findings and lung injury after transplantation. Pre-HCT screening with the combination of 3 modalities, reflecting different domains of respiratory status (function, structure, and microbial colonization), reveals important abnormalities in a substantial number of patients. Whether this improves patient outcome requires further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 9, September 2015, Pages 1622–1626
نویسندگان
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