کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2102072 1546280 2014 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Conditioning Chemotherapy Dose Adjustment in Obese Patients: A Review and Position Statement by the American Society for Blood and Marrow Transplantation Practice Guideline Committee
ترجمه فارسی عنوان
تنظیم مقررات جراحی شیمی درمانی در بیماران چاق: بیانیه ای برای بررسی و موضعی توسط کمیته راهنمایی انجمن آمریکایی برای پیوند خون و مغز
کلمات کلیدی
چاقی، پیوند سلول هماتوپوئیت، رژیمهای آماده سازی، دوز
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

Hematopoietic stem cell transplantation (HCT) is a potentially life-saving therapy for patients with malignant and nonmalignant disease states. This article reviews the current published literature on the dosing of pharmacologic agents used for HCT preparative regimens with specific focus on the obese patient population. The review found that dose adjustments for obesity have, to date, been based empirically or extrapolated from published data in the nontransplantation patient population. As a result, the Committee determined that clear standards or dosing guidelines are unable to be made for the obese population because Level I and II evidence are unavailable at this time. Instead, the Committee provides a current published literature review to serve as a platform for conditioning agent dose selection in the setting of obesity. A necessary goal should be to encourage future prospective trials in this patient population because further information is needed to enhance our knowledge of the pharmacokinetics and pharmacodynamics of conditioning agents in the setting of obesity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 20, Issue 5, May 2014, Pages 600–616
نویسندگان
, , , , , , , , , ,