کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2103681 1546358 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cell-Based Therapies for Osteonecrosis of the Femoral Head
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Cell-Based Therapies for Osteonecrosis of the Femoral Head
چکیده انگلیسی

Osteonecrosis of the femoral head is a disabling condition and a known complication of hematopoietic cell transplants (HCT). It is characterized by empty lacunae in the osseous matrix and necrotic marrow elements. The most important risk factor in HCT recipients is steroid exposure, frequently in the context of graft-versus-host disease. Current treatment is surgical, and involves decompression of the affected area and the use of bone grafts or hip arthroplasty. Cellular-based therapies are now under investigation, and can be used in addition to, or instead of, invasive surgery. This review presents an overview of osteonecrosis with particular emphasis on HCT recipients and introduces the role of cell therapy, especially with mesenchymal stromal cells, as a promising new treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 14, Issue 10, October 2008, Pages 1081–1087
نویسندگان
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