کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2104725 1546384 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adoptive Therapy with T Cells/NK Cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Adoptive Therapy with T Cells/NK Cells
چکیده انگلیسی

Graft-versus-tumor effect is well recognized in allogeneic transplantation, but it appears to be disease specific and relapse remains a significant problem. Furthermore, immune reconstitution after hematopoietic cell transplantation is often delayed and incomplete. It is becoming increasingly clear that the immune system is complex and that cooperation between innate and adaptive immunity is required to induce a productive immune response. Progress in clinically applicable cell separation techniques and knowledge of the signals required for effective immune activation have made adoptive therapy with T cells and NK cells a viable treatment option. However, clinical efficacy with either cell type depends on in vivo expansion of the infused product, which is facilitated through mechanisms that are active after lymphodeletion. Although successes have been seen with several approaches, further study of immune biology, lymphocyte cooperation and the role of regulatory T cells will lead to better strategies to exploit adoptive transfer of lymphocytes for therapeutic benefit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Supplement 1, January 2007, Pages 33–42
نویسندگان
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