کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2104736 1546384 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation: Current Perspectives
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Reduced Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation: Current Perspectives
چکیده انگلیسی

Allogeneic HCT after myeloablative conditioning is an effective therapy for patients with hematologic malignancies. In an attempt to extend this therapy to older patients or those with comorbidities, reduced intensity or truly nonmyeloablative regimens have been developed over the past decade. The principle underlying reduced intensity regimens is to provide some tumor kill with lessened regimen-related morbidity and mortality and then rely on graft-versus-tumor (GVT) effects to eradicate remaining malignant cells, whereas nonmyeloablative regimens rely primarily on GVT effects. In this article, 3 representative approaches are described, demonstrating the clinical application for hematopoietic and nonhematopoietic malignancies. Current challenges include controlling GVHD while allowing GVT to occur. In the future, clinical trials using reduced intensity and nonmyeloablative conditioning will be compared with myeloablative conditioning in selected malignancies to extend the application to standard-risk patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Supplement 1, January 2007, Pages 87–97
نویسندگان
, , ,