کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2105025 1546379 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hematopoietic Cell Transplantation for Chronic Lymphocytic Leukemia: An Evolving Concept
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Hematopoietic Cell Transplantation for Chronic Lymphocytic Leukemia: An Evolving Concept
چکیده انگلیسی

Recent years have brought major strides to our understanding of prognostic pathobiologic factors in patients with chronic lymphocytic leukemia. This has allowed identification of high-risk patients who may benefit from more aggressive therapies, including hematopoietic cell transplantation. High-dose chemotherapy followed by autologous hematopoietic cell transplantation is feasible, and results in encouraging responses, including molecular responses, with low transplant-associated mortality. However, it has failed to show a plateau effect on survival curves. On the other hand, there is convincing evidence that immunologically mediated graft-versus-leukemia effect of donor T cells are responsible for lowering the incidence of relapse and allowing possible “cure” in allograft recipients, albeit at the expense of high treatment-associated mortality using conventional myeloablation. Reducing the intensity of conditioning regimens has translated into lesser toxicity with reasonable preservation of its curative potential. Autologous or allogeneic hematopoietic cell transplantation in high-risk chronic lymphocytic leukemia remain promising and evolving treatment options. Treatment of CLL should consider stratification according to modern prognostic markers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 4, April 2007, Pages 373–385
نویسندگان
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