کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2120919 1085764 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prevention of Primary Cytomegalovirus Infection in Pregnancy
ترجمه فارسی عنوان
پیشگیری از ابتلا به عفونت سیتومگالوویروس در بارداری
کلمات کلیدی
سیتومگالوویروس، عفونت اولیه، بارداری، جلوگیری، اقدامات بهداشتی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• The rate of CMV seroconversion was 4/331 (1.2%) in the intervention group vs 24/315 (7.6%) in the comparison group
• This study shows that hygiene information of CMV-seronegative pregnant women significantly prevents maternal infection.
• 93% participants in the study found hygiene recommendations worth suggesting to all pregnant women.Cytomegalovirus is the leading infectious agent causing congenital sensorineural hearing loss and psychomotor retardation. Contacts with young children have been identified as the main source of virus transmission to mothers. While waiting for a CMV vaccine to become available, this study documents that an intervention based on the identification and hygiene counseling of pregnant women susceptible to be infected by CMV for the first time during pregnancy, significantly prevents maternal infection.

BackgroundCytomegalovirus (CMV) is the leading infectious agent causing congenital sensorineural hearing loss and psychomotor retardation. CMV vaccine is currently unavailable and treatment options in pregnancy are limited. Susceptible pregnant women caring for children are at high risk for primary infection. CMV educational and hygienic measures have the potential to prevent primary maternal infection.MethodsA mixed interventional and observational controlled study was conducted to investigate the effectiveness of hygiene information among pregnant women at risk for primary CMV infection for personal/occupational reasons. In the intervention arm, CMV-seronegative women, identified at the time of maternal serum screening for fetal aneuploidy at 11–12 weeks of gestation, were given hygiene information and prospectively tested for CMV until delivery. The comparison arm consisted of women enrolled at delivery who were neither tested for nor informed about CMV during pregnancy, and who had a serum sample stored at the screening for fetal aneuploidy. By design, groups were homogeneous for age, parity, education, and exposure to at least one risk factor. The primary outcome was CMV seroconversion. Acceptance of hygiene recommendations was a secondary objective and was measured by a self-report.FindingsFour out of 331 (1.2%) women seroconverted in the intervention group compared to 24/315 (7.6%) in the comparison group (delta = 6.4%; 95% CI 3.2–9.6; P < 0.001). There were 3 newborns with congenital infection in the intervention group and 8 in the comparison group (1 with cerebral ultrasound abnormalities at birth). Ninety-three percent of women felt hygiene recommendations were worth suggesting to all pregnant women at risk for infection.InterpretationThis controlled study provides evidence that an intervention based on the identification and hygiene counseling of CMV-seronegative pregnant women significantly prevents maternal infection. While waiting for CMV vaccine to become available, the intervention described may represent a responsible and acceptable primary prevention strategy to reduce congenital CMV.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EBioMedicine - Volume 2, Issue 9, September 2015, Pages 1205–1210
نویسندگان
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