Pathophysiologic Response to Burns in the Elderly

• The outcome of elderly burn management is low with reasons that remain unclear.
• Elderly have a higher mortality, more premorbid conditions and a higher incidence of multi organ failure.
• Elderly stay at the hospital for longer time.
• The incidence of infection or sepsis is not higher than young adult.
• Elderly show delayed hyper-metabolic response, increased hyperglycemic and hyperlipidemic responses.
• Elderly present inversed inflammatory response.
• Elderly show substantial delay in wound healing, predominantly due to alteration in characteristics of progenitor cells.Despite advancements in treatment of severely burned patients, the death rate is still high in elderly. In this project, we investigate the reason behind this poor outcome. Our report highlights some of the deficiencies that we have observed in elderly patients and compare them to the young adults. Elderly have late immune responses which are necessary to fight the disease. Their body lacks some of the essential stem cells which are essential for skin healing. By learning the major deficiencies that come with this age group, we will be able to help elderly who have been subjected to burn injury.

Over the last decades advancements have improved survival and outcomes of severely burned patients except one population, elderly. The Lethal Dose 50 (LD50) burn size in elderly has remained the same over the past three decades, and so has morbidity and mortality, despite the increased demand for elderly burn care. The objective of this study is to gain insights on why elderly burn patients have had such a poor outcome when compared to adult burn patients. The significance of this project is that to this date, burn care providers recognize the extreme poor outcome of elderly, but the reason remains unclear. In this prospective translational trial, we have determined clinical, metabolic, inflammatory, immune, and skin healing aspects. We found that elderly have a profound increased mortality, more premorbid conditions, and stay at the hospital for longer, p < 0.05. Interestingly, we could not find a higher incidence of infection or sepsis in elderly, p > 0.05, but a significant increased incidence of multi organ failure, p < 0.05. These clinical outcomes were associated with a delayed hypermetabolic response, increased hyperglycemic and hyperlipidemic responses, inversed inflammatory response, immune-compromisation and substantial delay in wound healing predominantly due to alteration in characteristics of progenitor cells, p < 0.05. In summary, elderly have substantially different responses to burns when compared to adults associated with increased morbidity and mortality. This study indicates that these responses are complex and not linear, requiring a multi-modal approach to improve the outcome of severely burned elderly.