کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2136475 1547907 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IKZF1 (IKAROS) deletions in B-ALL and its clinical correlation: A prospective study from a tertiary care centre in Northern India
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
IKZF1 (IKAROS) deletions in B-ALL and its clinical correlation: A prospective study from a tertiary care centre in Northern India
چکیده انگلیسی


• IKZF1 deletions were detected in >25% of B-ALL patients.
• Haploinsufficiency deletions were commoner than dominant negative deletions.
• IKZF1 deletion correlated with higher induction failure rate in B-ALL.

IntroductionIKZF1 deletions have been reported with variable frequency in B-ALL. This study was carried out to find the prevalence and profile of IKZF1 deletions and their correlation in B-ALL.MethodsThe untreated B-ALL cases were prospectively analyzed for IKZF1 deletions over a period of eleven months using multiplex ligation dependent probe amplification (MLPA). The IKZF1 deletions were classified into three functional groups—dominant negative, haploinsufficiency and others. The response to induction chemotherapy was correlated with the IKZF1 deletion status.ResultsThe median age of 101 cases was 7 years (1–67) with 82 pediatric (<18 years) cases. Fifteen cases were positive for BCR-ABL. The IKZF1 deletions were detected in 29 (28.7%) cases; 53% BCR-ABL positive, 24% BCR-ABL negative, 47% adult and 24% pediatric cases. Out of the 29 deletions, 19 (66%) were haploinsufficiency, 8 (28%) were dominant negative and 2 others. The IKZF1 deleted cases had higher induction failure rates compared to the cases without IKZF1 deletions.ConclusionsThe IKZF1 deletions were detected in 28.7% B-ALL patients. These were more common in BCR-ABL positive and adult B-ALL compared to the BCR-ABL negative and pediatric cases, respectively. The haploinsufficiency was commoner than dominant negative IKZF1 deletions. IKZF1 deletions correlated with higher induction failure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 41, February 2016, Pages 7–11
نویسندگان
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