Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway

• Heme oxygenase-1 (HO-1) is aberrantly overexpressed in the majority of AML patients.
• HO-1 has an effect on the apoptosis of AML cell lines.
• Overexpression of HO-1 accelerates leukemia's progression in vivo.
• HO-1 suppresses the apoptosis of AML cells through activating JNK/c-JUN signaling pathway.

There are few studies on the correlation between heme oxygenase-1 (HO-1) and acute myeloid leukemia (AML). We found that HO-1 was abe