کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2136577 | 1087798 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
N-Cadherin and Tie2 positive CD34+CD38−CD123+ leukemic stem cell populations can develop acute myeloid leukemia more effectively in NOD/SCID mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Emerging studies suggest that the population of malignant cells found in human acute myelogenous leukemia (AML) arises from a rare population of leukemic stem cells (LSCs). A lot of investigators have reported the identification of cell surface markers, such as CD123. Here, we report the identification of N-cadherin and Tie2 as LSCs markers. Inoculation of CD34+CD38−CD123+N-cadherin+ and CD34+CD38−CD123+ Tie2+ population can induce leukemia in NOD/SCID mice. The leukemic blast cells from the primary leukemic mice could also induce leukemia in the secondary transplantation. These findings suggested that N-cadherin and Tie2 were the important markers that can assist in leukemia development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 38, Issue 5, May 2014, Pages 632–637
Journal: Leukemia Research - Volume 38, Issue 5, May 2014, Pages 632–637
نویسندگان
Shaowei Qiu, Yujiao Jia, Haiyan Xing, Tengteng Yu, Jing Yu, Pei Yu, Kejing Tang, Zheng Tian, Huijun Wang, Yingchang Mi, Qing Rao, Min Wang, Jianxiang Wang,