Insights in Hodgkin Lymphoma angiogenesis

• Angiogenesis is a hallmark of tumor growth and progression in malignancies.
• Data concerning the angiogenesis of HL are limited if compared with non-HL.
• Studies of angiogenesis inhibitors demonstrated antitumor effects in HL.

Angiogenesis is a hallmark of tumor growth and progression in solid and hematological malignancies. Different cellular components of the tumor microenvironment such as macrophages, mast cells, circulating endothelial cells and angiogenic factors, including vascular endothelial growth factor and its receptors are involved in the maintenance of Hodgkin Lymphoma. In this review article, we highlight relevant literature focusing on the relationships between angiogenesis and Hodgkin Lymphoma as well as discussing anti-angiogenic treatments in this malignancy.