کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2136654 1087807 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Appropriate use of bendamustine in first-line therapy of chronic lymphocytic leukemia. Recommendations from SIE, SIES, GITMO Group
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Appropriate use of bendamustine in first-line therapy of chronic lymphocytic leukemia. Recommendations from SIE, SIES, GITMO Group
چکیده انگلیسی


• By using the GRADE system we produced recommendations on 3 key issues on the use of bendamustine in the front line setting in CLL.
• Bendamustine with rituximab was recommended in elderly fit patients potentially eligible to FCR.
• Bendamustine alone was recommended in patients who are candidate to chlorambucil alone.
• Rituximab–bendamustine was recommended in patients not eligible to FCR, but suitable to receive rituximab.
• Consensus-based recommendations addressed evidence-orphan issues on the use of this drug in the front-line setting in CLL.

By using the GRADE system we produced the following recommendations for the use of bendamustine in the first-line treatment of CLL: (1) bendamustine with rituximab is recommended in elderly fit patients potentially eligible to FCR; (2) Bendamustine alone is recommended in patients who are candidate to chlorambucil alone; (3) Rituximab–bendamustine is recommended in patients not eligible to FCR, but suitable to receive rituximab. Consensus-based recommendations addressed evidence-orphan issues concerning the use of bendamustine in genetically-defined high-risk patients and the appropriate dose of bendamustine as single agent or in association with rituximab.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 38, Issue 11, November 2014, Pages 1269–1277
نویسندگان
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