کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2136659 | 1087807 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Acute leukemias caused by translocations of the MLL gene at chromosome 11 band q23 (11q23) are characterized by a unique gene expression profile. More recently, data from several laboratories indicate that the most commonly encountered MLL fusion proteins, MLLT1, MLLT3, and AFF1 are found within a molecular complex that facilitates the elongation phase of mRNA transcription. Mutational analyses suggest that interaction between the MLLT1/3 proteins and AFF family proteins are required for experimental transformation of hematopoietic progenitor cells (HPCs). Here, we define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL-mediated transformation of HPCs. Our findings, coupled with the newly defined structure of MLLT3 in complex with AFF1, should facilitate the development of small molecules that block this amino acid interaction and interfere with the activity of the most common MLL oncoproteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 38, Issue 11, November 2014, Pages 1309-1315
Journal: Leukemia Research - Volume 38, Issue 11, November 2014, Pages 1309-1315
نویسندگان
Alyson A. Lokken, Nicholas J. Achille, Ming-Jin Chang, Jeffrey J. Lin, Aravinda Kuntimaddi, Benjamin I. Leach, Bhavna Malik, Jacqueline B. Nesbit, Shubin Zhang, John H. Bushweller, Nancy J. Zeleznik-Le, Charles S. Hemenway,