کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2136676 | 1087809 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AML with gain of chromosome 8 as the sole chromosomal abnormality (+8sole) is associated with a specific molecular mutation pattern including ASXL1 mutations in 46.8% of the patients
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Trisomy 8 is the most frequent cytogenetically gained aberration in AML. We compared 79 adult de novo AML with trisomy 8 as the sole cytogenetic abnormality (+8sole) to 511 normal karyotype AML patients (NK). +8sole patients were older (p = 0.013), presented lower WBC counts (p = 0.010), harbored more often ASXL1 mutations (p < 0.001) and RUNX1 mutations (p = 0.009), but less frequent FLT3-ITD (p = 0.038), NPM1 mutations (p < 0.001) and double-mutated CEBPA (p = 0.038) than NK patients. No prognostic difference was found between +8sole and NK. With respect to genetic stability we found +8sole was instable, and molecular markers were either stable or gained in number and diversity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 39, Issue 3, March 2015, Pages 265-272
Journal: Leukemia Research - Volume 39, Issue 3, March 2015, Pages 265-272
نویسندگان
Tamara Alpermann, Claudia Haferlach, Christiane Eder, Niroshan Nadarajah, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Susanne Schnittger,