کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2136822 | 1087813 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sequence of novel agents in multiple myeloma: An instrumental variable analysis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Lenalidomide and bortezomib have not been compared prospectively and are currently used in sequence for patients with multiple myeloma; however, it is unknown whether a sequence of administration could result in improved outcomes. We retrospectively reviewed electronic records of patients with multiple myeloma who had used both agents in sequence at our institution: 97 patients had lenalidomide first and 111 had bortezomib first. On multivariable analysis, the sequence of therapy was not associated with outcome. These findings were confirmed with instrumental variable analyses. Finally, use of bortezomib first was associated with improved survival for patients with baseline renal insufficiency.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 37, Issue 9, September 2013, Pages 1077–1082
Journal: Leukemia Research - Volume 37, Issue 9, September 2013, Pages 1077–1082
نویسندگان
Rachid Baz, Branko Miladinovic, Amila Patel, Viet Q. Ho, Kenneth H. Shain, Melissa Alsina, Taiga Nishihori, Jose L. Ochoa-Bayona, Daniel M. Sullivan, William S. Dalton, Benjamin Djulbegovic,