کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2137051 | 1087831 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Integrating post induction WT1 quantification and flow-cytometry results improves minimal residual disease stratification in acute myeloid leukemia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Fifty uniformly treated adult AML patients were analyzed with respect to pre-treatment and post-induction risk factors. Forty-two patients achieving complete hematological remission were assessed for minimal residual disease (MRD) by WT1 gene expression; 34 by flow-cytometry (flow-MRD). Patients who were flow-MRD negative had a better 3-year disease-free (DFS; 79.5% vs. 27.3%; p = .032) compared with patients who were still positive after induction. Interestingly, DFS of flow-MRD positive patients was not related to the amount of flow-detected clone population (⥠or <1%, p = .41) but to WT1 reduction (ÎWT1, 3-year DFS; 46.2% vs. 0% if ÎWT1 was ⥠or < of 1.5 log, p = .001). In AML, combining MRD results provided by WT1 quantification and flow-cytometry improves the reliability of MRD-based prognostic stratification. Similar analyses by further larger studies should be advocated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 37, Issue 12, December 2013, Pages 1606-1611
Journal: Leukemia Research - Volume 37, Issue 12, December 2013, Pages 1606-1611
نویسندگان
Carlo Marani, Marino Clavio, Raffaella Grasso, Nicoletta Colombo, Fabio Guolo, Annalisa Kunkl, Filippo Ballerini, Livia Giannoni, Chiara Ghiggi, Giuseppina Fugazza, Jean-Louis Ravetti, Marco Gobbi, Maurizio Miglino,