کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2137162 1087834 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A combination of thalidomide and arsenic trioxide is effective and well tolerated in patients with myelodysplastic syndromes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
A combination of thalidomide and arsenic trioxide is effective and well tolerated in patients with myelodysplastic syndromes
چکیده انگلیسی

Twenty-two patients with myelodysplastic syndromes (MDS) were treated with thalidomide plus arsenic trioxide (ATO). Twenty-two MDS patients receiving supportive care were used as controls. The remission was achieved in 4 patients (18.2%) receiving thalidomide/ATO, and none in the control group (p < 0.05). Fifteen of 22 patients in the treatment group achieved hematologic improvement (68.2% vs. 27.3% in the control, p < 0.05). The progression-free survival was longer in the treatment group than that in the control (26 vs. 10 months, p < 0.05). The overall survival was also longer in the treatment group than that in the control (36 vs. 16 months, p < 0.05). No severe adverse reactions were observed. These preliminary findings suggest that thalidomide/ATO combination treatment is effective and safe for MDS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 36, Issue 6, June 2012, Pages 715–719
نویسندگان
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