Possibility of myelodysplastic syndromes screening using a complete blood automated cell count

Diagnosis of MDS has changed during the last years because of the 2008 WHO classification. Complete blood cell count (CBC) is a very important tool both for diagnosis of MDS.The aim of this study was to evaluate if it is possible to use the abnormal signals produced by dysplastic cells to produce a flag “dysplasia” able to identify the patients needing further hematological investigations. The proposed flag has been tested in a large group of patients to evaluate the sensibility and specificity. We create 5 patterns of MDS. Our study demonstrated that the flag “dysplasia” is specific and sensible for MDS.