کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2137288 1087842 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia
چکیده انگلیسی

Mutations and/or overexpression of c-Kit proto-oncogene frequently occur in subsets of acute myeloid leukemia (AML) and contribute to abnormal cell proliferation and poor outcomes. We showed that c-Kit expression was subject to post-transcriptional regulation by microRNA (miRNA)-193b. Notably, miR-193b was significantly down-regulated in the examined AML cells and its levels were inversely correlated with c-Kit levels. Restoration of miR-193b expression in AML cells resulted in distinctly reduced c-Kit expression and inhibited cell growth. These data reveal a role for miR-193b dysregulation in myeloid leukemogenesis and the therapeutic promise of regulating miR-193b expression for c-Kit-positive AML.


► The expression of c-Kit was subject to post-transcriptional regulation by miR-193b.
► MiR-193b was down-regulated in AML cells and inversely correlated with c-Kit levels.
► Restoration of miR-193b in AML cells reduced c-Kit levels and inhibited cell growth.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 35, Issue 9, September 2011, Pages 1226–1232
نویسندگان
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