کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2137504 | 1087847 | 2012 | 6 صفحه PDF | دانلود رایگان |
WT1 levels may be a useful predictor of leukemia free survival (LFS) following treatment of acute myeloid leukemia (AML). We report a retrospective study in which levels of WT1 expression from patients with de novo AML were measured from bone marrow and peripheral blood at diagnosis, post-induction, post-consolidation and relapse. We demonstrate that higher levels of WT1 in peripheral blood at diagnosis are associated with poorer LFS independent of age and cytogenetic risk-group (n = 85, p = 0.028). When measured at post-consolidation, the presence of detectable WT1 is associated with poorer LFS in univariate analysis of both peripheral blood (p = 0.024) and bone marrow (p = 0.019). In a multivariate analysis including age and cytogenetic risk, the association remained significant for bone marrow (p = 0.016) with a trend observed for peripheral blood (p = 0.06). These findings have formed the basis for ongoing research.
Journal: Leukemia Research - Volume 36, Issue 4, April 2012, Pages 453–458