Aberrant proplatelet formation in chronic myeloproliferative neoplasms

Proplatelets represent pseudopodia of megakaryocytes which extend into bone marrow sinuses to release platelets. Proplatelets were visualized by immunohistochemical and confocal microscopy. In trephines from essential thrombocythaemia (ET, n = 10), fibrotic (n = 10) and pre-fibrotic