کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2137608 1087852 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Miniaturized flow cytometry-based BCR-ABL immunoassay in detecting leptomeningeal disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Miniaturized flow cytometry-based BCR-ABL immunoassay in detecting leptomeningeal disease
چکیده انگلیسی

Despite central nervous system (CNS) prophylactic programs limit leptomeningeal involvement in acute lymphoblastic leukemia (ALL), it can still occur in a restricted percentage of cases. The exact risk rate remains still unknown, and several factors are associated with an increased probability to develop CNS involvement. Among them, Philadelphia (Ph)-positive genotype seems to play a relevant role. Recently, a flow cytometric assay to detect BCR-ABL protein has been developed, but little is known about its possible employment in leptomeningeal disease. Here, we show the miniaturized application of the original assay for BCR-ABL oncoprotein detection in cerebrospinal fluid (CSF) samples.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 35, Issue 10, October 2011, Pages 1290–1293
نویسندگان
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