کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2137631 | 1087852 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Saliva is a reliable and practical source of germline DNA for genome-wide studies in chronic lymphocytic leukemia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Saliva is a reliable and practical source of germline DNA for genome-wide studies in chronic lymphocytic leukemia Saliva is a reliable and practical source of germline DNA for genome-wide studies in chronic lymphocytic leukemia](/preview/png/2137631.png)
چکیده انگلیسی
High-throughput genomics requires tumor DNA matched to germline DNA, that cannot be easily obtained in the context of leukemia. Using chronic lymphocytic leukemia as a model, saliva DNA was frequently devoid of tumor DNA also during overt disease, and passed quality controls for SNP-array (77/102, 75.4%) and next generation sequencing (71/102, 69.6%). Compared to saliva, urine provides germline DNA of similar quality but in lower amounts. Saliva DNA was successfully run on SNP 6.0 arrays, and passed quality control call rate thresholds. On these bases, saliva represents a useful source of germline DNA for high-throughput genomic studies of hematologic neoplasia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 35, Issue 10, October 2011, Pages 1419–1422
Journal: Leukemia Research - Volume 35, Issue 10, October 2011, Pages 1419–1422
نویسندگان
Silvia Rasi, Alessio Bruscaggin, Andrea Rinaldi, Stefania Cresta, Marco Fangazio, Lorenzo De Paoli, Sara Monti, Ernesto Gargiulo, Ivo Kwee, Robin Foà, Francesco Bertoni, Gianluca Gaidano, Davide Rossi,