کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2137694 | 1087856 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Murine models of disease are vital to the understanding of pathogenesis and the development of novel therapeutics. We have previously established interleukin (IL)-15 transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells, followed by spontaneous transformation to lethal leukemia. Herein, we have characterized this model, which has many features in common with the aggressive variants of NK and T large granular lymphocyte leukemia (LGLL) in humans. The LGLL blasts are cytolytic and produce IFN-γ ex vivo. Cytogenetic analysis revealed trisomy of chromosome 17 and/or 15. This model should provide opportunities to develop effective standard therapies for this fatal disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 34, Issue 2, February 2010, Pages 203–209
Journal: Leukemia Research - Volume 34, Issue 2, February 2010, Pages 203–209
نویسندگان
Akihiko Yokohama, Anjali Mishra, Takeki Mitsui, Brian Becknell, Jessica Johns, Douglas Curphey, Bradley W. Blaser, Jeffrey B. VanDeusen, Hsiaoyin Mao, Jianhua Yu, Michael A. Caligiuri,