کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2137728 1087857 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Level of DNA topoisomerase IIα mRNA predicts the treatment response of relapsed acute leukemic patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Level of DNA topoisomerase IIα mRNA predicts the treatment response of relapsed acute leukemic patients
چکیده انگلیسی
The DNA topoisomerase IIα (Topo IIα) is known as a target enzyme for many chemotherapeutic agents. We investigated the Topo IIα mRNA expression by real-time RT-PCR in 37 paired samples at diagnosis and at relapse of acute leukemic patients in relation to drug sensitivity and clinical outcome. The Topo IIα levels in leukemic blasts at relapse were significantly higher than that at diagnosis, especially in ALL. The increase in the Topo IIα level at relapse was significant in cases which could not achieve a second remission, but not significant in cases which achieved a second remission. These results suggest that the change of Topo IIα expression in leukemic blasts at relapse may predict therapeutic responsiveness.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 33, Issue 7, July 2009, Pages 902-907
نویسندگان
, , , , , , ,