کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2137738 1087857 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thalidomide treatment down-regulates SDF-1α and CXCR4 expression in multiple myeloma patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Thalidomide treatment down-regulates SDF-1α and CXCR4 expression in multiple myeloma patients
چکیده انگلیسی

The chemokine stromal-derived factor-1α (SDF-1α) and its receptor CXCR4 are critically involved in directional migration and homing of plasma cells in multiple myeloma. Here, we show that the expression of SDF-1α and CXCR4 was significantly down-regulated in patients treated with thalidomide (n = 10) as compared to newly diagnosed MM patients (n = 31) and MM patients treated with other drugs (n = 38). SDF-1 α and CXCR4 expression was also significantly decreased in a RPMI 8226 cell line treated with 10 and 20 μmol/L of thalidomide. Our findings indicate that thalidomide therapy induces down-regulation of CXCR4 and its ligand SDF-1α in multiple myeloma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 33, Issue 7, July 2009, Pages 970–973
نویسندگان
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