کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2137738 | 1087857 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thalidomide treatment down-regulates SDF-1α and CXCR4 expression in multiple myeloma patients
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
The chemokine stromal-derived factor-1α (SDF-1α) and its receptor CXCR4 are critically involved in directional migration and homing of plasma cells in multiple myeloma. Here, we show that the expression of SDF-1α and CXCR4 was significantly down-regulated in patients treated with thalidomide (n = 10) as compared to newly diagnosed MM patients (n = 31) and MM patients treated with other drugs (n = 38). SDF-1 α and CXCR4 expression was also significantly decreased in a RPMI 8226 cell line treated with 10 and 20 μmol/L of thalidomide. Our findings indicate that thalidomide therapy induces down-regulation of CXCR4 and its ligand SDF-1α in multiple myeloma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 33, Issue 7, July 2009, Pages 970–973
Journal: Leukemia Research - Volume 33, Issue 7, July 2009, Pages 970–973
نویسندگان
Adriana Morgan Oliveira, Durvanei Augusto Maria, Martin Metzger, Camila Linardi, Ricardo Rodrigues Giorgi, Fernanda Moura, Gracia Aparecida Martinez, Sérgio Paulo Bydlowski, Estela Maria Novak,