کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2137904 | 1087862 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
mRNA expression of matrix metalloproteinases (MMPs) 2 and 9 and tissue inhibitor of matrix metalloproteinases (TIMPs) 1 and 2 in childhood acute lymphoblastic leukemia: Potential role of TIMP1 as an adverse prognostic factor
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR. A significant association was observed between higher expression levels of MMP9 and low risk group and absence of extramedullary infiltration and higher expression levels of TIMP2 and MMP2 with T-ALL. TIMP1 gene expression values higher than the median were associated with a significantly lower 5-year event free-survival in univariable (PÂ =Â 0.04) and multivariable analysis (PÂ =Â 0.01). Our data address new information in the complex interaction of the migration/adhesion genes and childhood ALL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 34, Issue 1, January 2010, Pages 32-37
Journal: Leukemia Research - Volume 34, Issue 1, January 2010, Pages 32-37
نویسندگان
Carlos Alberto Scrideli, Maria Angélica Abdala Cortez, José Andres Yunes, Rosane Gomes de Paula Queiróz, Elvis Terci Valera, Juliana França da Mata, Silvia Regina Caminada Toledo, Priscila Pavoni-Ferreira, Maria Lúcia de Martino Lee,