کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2137915 1087862 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Susceptibility of mantle cell lymphomas to reovirus oncolysis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Susceptibility of mantle cell lymphomas to reovirus oncolysis
چکیده انگلیسی
Mantle cell lymphoma (MCL) an incurable B-cell, non-Hodgkin lymphoma (NHL) urgently requires new treatments. We assessed reovirus mediated oncolysis in a panel of human MCL cell lines. In vitro, we found the cytopathic effect of reovirus infection ranged from high to very limited and correlated with levels of Ras activation. In vivo, a single reovirus injection intra-tumorally resulted in complete regression of both the injected and the contra-lateral tumor in a subcutaneous bi-tumor model, in one out of three cell lines tested. Reovirus treatment of MCL seems feasible but will need to be guided by the presence of molecular determinants of reovirus susceptibility.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 34, Issue 1, January 2010, Pages 100-108
نویسندگان
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