کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2137980 | 1087864 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of mitochondrial function reduces DNA repair in human mononuclear cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
BackgroundMitochondria provide ATP and Ca2+ needed for DNA repair, but also produce reactive oxygen species (ROS), which may damage DNA.AimTo investigate the effect of mitochondrial function inhibition on DNA repair.MethodFive mitochondrial inhibitors acting at various sites of electron transport were studied. Human peripheral blood mononuclear cells, spontaneous and H2O2-indcued DNA repair, as well as %-double-stranded-DNA, were measured.ResultsAll mitochondrial inhibitors suppressed spontaneous and H2O2-induced DNA repair. However, their effect on %-double-stranded-DNA differed, which is partly related to ROS suppression.ConclusionMitochondrial inhibition may enhance efficacy and reduce toxicity of radiation and cytotoxic drugs therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 35, Issue 2, February 2011, Pages 219–225
Journal: Leukemia Research - Volume 35, Issue 2, February 2011, Pages 219–225
نویسندگان
Anat Gafter-Gvili, Michal Herman, Yaacov Ori, Asher Korzets, Avry Chagnac, Boris Zingerman, Benaya Rozen-Zvi, Uzi Gafter, Tsipora Malachi,