کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2138317 | 1087873 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
‘Idiopathic’ eosinophilia with an Occult T-cell clone: Prevalence and clinical course
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
In a study of 99 consecutive patients with ‘idiopathic’ eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (∼8%) with an ‘Occult’ T-cell clone had predominantly cutaneous disease and FIP1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec® treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3–8 years of eosinophilic prodrome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 31, Issue 5, May 2007, Pages 691–694
Journal: Leukemia Research - Volume 31, Issue 5, May 2007, Pages 691–694
نویسندگان
C. Vaklavas, A. Tefferi, J. Butterfield, R. Ketterling, S. Verstovsek, H. Kantarjian, A. Pardanani,