کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138459 1087877 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aberrant microRNA expression pattern in myelodysplastic bone marrow cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Aberrant microRNA expression pattern in myelodysplastic bone marrow cells
چکیده انگلیسی

The microRNA/miR system might contribute to deregulation of cell homeostasis/disease phenotype. This is the first approach to generate an expression profile of 365 microRNAs in myelodysplastic syndromes (MDS) with normal karyotype (n = 12) and distinct cytogenetic aberrations (n = 12).In MDS-del(5q), a series of microRNAs not in the 5q-region was increased. MicroRNAs encoded on chromosomes 5, 7 and 8 were not differentially expressed in MDS with del(5q), −7 or +8. Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS.These findings provide evidence that MDS-haematopoiesis is distinct in its microRNA-expression pattern from non-neoplastic cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 34, Issue 9, September 2010, Pages 1169–1174
نویسندگان
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