کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2138538 | 1087879 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma](/preview/png/2138538.png)
چکیده انگلیسی
Centrosome amplification (CA) as a potential marker of mitotic disruptions in multiple myeloma (MM) was investigated in two populations of B-cell lineage: B-cells and plasma cells (PCs). Using immunofluorescent staining, it was shown that CA in B-cells is present in 3.2 ± 2.5% in healthy donors versus 9.9 ± 7.9% in MM patients (p < 0.0001). Based on the calculated threshold value of CA in B-cells, 37% (14/38) of MM patients were positive. There was no significant correlation between CA-positive MM cases (based on PC samples evaluation) and the occurrence of cytogenetic abnormalities in PCs, including del(13)(q14), del(17)(p13), gain(1)(q21) and hyperdiploidy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 34, Issue 8, August 2010, Pages 1007–1011
Journal: Leukemia Research - Volume 34, Issue 8, August 2010, Pages 1007–1011
نویسندگان
E. Dementyeva, P. Nemec, F. Kryukov, K.R. Muthu Raja, J. Smetana, R. Zaoralova, H. Greslikova, R. Kupska, P. Kuglik, R. Hajek,