کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2138585 | 1087880 | 2009 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Phenotype of blasts in chronic myeloid leukemia in blastic phase—Analysis of bone marrow trephine biopsies and correlation with cytogenetics Phenotype of blasts in chronic myeloid leukemia in blastic phase—Analysis of bone marrow trephine biopsies and correlation with cytogenetics](/preview/png/2138585.png)
We identified different phenotypic subsets among 62 cases of chronic myeloid leukemia (CML) in blast crisis (BC) (26% B-lymphoblastic, and 74% various myeloblastic subsets) on bone marrow trephines and correlated the blast-phenotype with cytogenetics. Five of myeloid-BC had an associated 3q26 abnormality and two of these showed a megakaryoblastic-phenotype. While myeloid-BC was associated with additional copies of Philadelphia (Ph) (29%) (p = 0.08), numerical abnormalities (51%) (p = 0.007), trisomy-8 (29%) (p = 0.08) and 17p-loss (22%), none of lymphoid-BC showed these abnormalities. Among myeloid-BC, CD34-negative cases were more often associated with trisomy-8, 17p-loss and numerical abnormalities, and the CD117-negative subset with additional copies of Ph (p < 0.05).
Journal: Leukemia Research - Volume 33, Issue 3, March 2009, Pages 418–425