کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138681 1087883 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The significance of bone marrow cell morphology and its correlation with cytogenetic features in the diagnosis of MDS-RA patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
The significance of bone marrow cell morphology and its correlation with cytogenetic features in the diagnosis of MDS-RA patients
چکیده انگلیسی

Besides cytopenia, dysplasia is crucial characteristic of MDS-RA. To summarize the morphological features that contribute to the diagnosis of MDS-RA, 48 RA patients with abnormal karyotype were analyzed for the features of morphological and cytogenetical abnormalities and the relationships between them. 46 MDS-RA patients with normal karyotype and 207 patients with non-MDS anemia were enrolled into control groups. More conspicuous and diverse dysplasia can be found in abnormal karyotype MDS-RA than those in control groups (P < 0.05). Apparent dysplasia in granulocyte and megakaryocytoid lineages may provide valuable evidence for the diagnosis. Dysplasia occurred more frequently in patients with severe chromosome abnormalities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 33, Issue 8, August 2009, Pages 1029–1038
نویسندگان
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