کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138737 1087884 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome
چکیده انگلیسی

We investigated whether, in myelodysplastic syndromes (MDS), aberrant expression of miR-150/miR-221/miR-222 and their designated target mRNA molecules MYB, p27 and c-KIT may be involved in insufficient haematopoiesis. In a series of MDS (n = 52), an aberrant increase of miR-150 was found only in MDS with associated del(5q) (n = 9; p < 0.01). The mRNA expression of transcription factor MYB, the designated target of miR-150, was shown to correlate inversely with the miR-150 level. Acute leukaemia evolving from MDS (n = 11) showed significantly decreased levels of miR-221 but not miR-222. We conclude that inhibition of proliferation via over-expressed miR-150 might contribute to myelodysplastic haematopoiesis in MDS-del(5q).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 34, Issue 3, March 2010, Pages 328–334
نویسندگان
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