کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138913 1087889 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mutagenic mechanisms in leukemia and cancer: A new concept: Cytosine lack could be as mutagenic as cytosine deamination
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Mutagenic mechanisms in leukemia and cancer: A new concept: Cytosine lack could be as mutagenic as cytosine deamination
چکیده انگلیسی

The molecular mechanisms involved in mutagenesis caused by nitrous acid, ultraviolet light and cytosine methylation are reviewed. All three mutagens lead to a GC → AT point mutation in the DNA molecule and the biochemical basis of these mutations in each case is the deamination of cytosine to uracil. It is shown that the lack of cytosine could be as mutagenic as the deamination of cytosine and it is shown schematically how cytosine lack could give rise to a population of genetically abnormal cells which are completely incapable of any degree of differentiation; a state perhaps reminiscent of the most acute of leukemias and the most anaplastic of cancers. A metabolic block in the amination of uracil to cytosine is suggested as a possible cause of the cytosine lack, a block whicl is unique in that it incorporates a mutagenic mechanism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 30, Issue 9, September 2006, Pages 1079–1083
نویسندگان
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