کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2138991 | 1087892 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML](/preview/png/2138991.png)
چکیده انگلیسی
The PML protein localizes to regions of the nucleus known as nuclear bodies or PODs. However, in t(15;17) Acute Promyelocytic Leukemia (APL) blasts, PML is found in a micro-punctate pattern. In order to test the hypothesis that delocalization of PML from PODs is necessary for APL, we investigated the interaction of the t(5;17) APL fusion protein NPM-RAR with PML. NPM-RAR localizes diffusely throughout the nucleoplasm. NPM-RAR does not alter the localization of PML in transfected HeLa cells, and does not associate with PML in vitro. These studies suggest that NPM-RAR does not interact with PML.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 30, Issue 8, August 2006, Pages 979–986
Journal: Leukemia Research - Volume 30, Issue 8, August 2006, Pages 979–986
نویسندگان
Elizabeth A. Rush, Kimberly W. Schlesinger, Simon C. Watkins, Robert L. Redner,