کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2139257 | 1087898 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia](/preview/png/2139257.png)
TCL-1 expression is variable in CLL, and no study has examined its association with treatment response. We measured TCL-1 protein in CLL cells from 51 patients who then received pentostatin, cyclophosphamide, and rituximab. TCL-1 expression did not correlate with any pre-treatment characteristics. Lower TCL-1 levels were associated with higher probability of attaining flow cytometry-negative status post-treatment (52% versus 17%, p = 0.046). Trends toward improved complete remission rate (49% versus 19%, p = 0.064) and progression-free survival (medians: 33 versus 20 months, p = 0.199) were noted with lower TCL-1 expression. These data suggest TCL-1 expression may help predict treatment outcome in CLL patients following chemoimmunotherapy, and examination in larger studies is warranted.
Journal: Leukemia Research - Volume 31, Issue 12, December 2007, Pages 1737–1740