کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2139284 | 1087899 | 2008 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression and function of the calcitonin receptor by myeloma cells in their osteoclast-like activity in vitro
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression and function of the calcitonin receptor by myeloma cells in their osteoclast-like activity in vitro Expression and function of the calcitonin receptor by myeloma cells in their osteoclast-like activity in vitro](/preview/png/2139284.png)
چکیده انگلیسی
Malignant plasma cells exert osteoclast-like activity in vitro. We investigated the function of the calcitonin (CT) receptor (R) on myeloma cells from patients and in myeloma cell lines. Primary myeloma cells expressed high CTR levels whereas the cell lines uniformly exposed the CTR-2 variant expressed by osteoclasts. Treatment of myeloma cell lines with CT modified the intracellular Ca2+ and cAMP levels, suggesting the activation of both PKC and PKA pathways, and abrogated their bone resorptive property as erosive pits on osteologic substrates. Thus, the expression, sensitivity and function of CTR-2 in myeloma cells emphasize their osteoclast-like behavior in vitro.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 32, Issue 4, April 2008, Pages 611-623
Journal: Leukemia Research - Volume 32, Issue 4, April 2008, Pages 611-623
نویسندگان
Franco Silvestris, Paola Cafforio, Monica De Matteo, Cosima Quatraro, Franco Dammacco,