کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2139310 | 1087900 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CDKN2A deletions in acute lymphoblastic leukemia of adolescents and young adults—An array CGH study
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Deletion in chromosome 9p involving the CDKN2A locus (9p21.3) is known in many malignancies. To detect this deletion in adolescent ALL patients we used oligo array CGH and studied 54 patients aged 10–25 years. Deletion rate was 25/54 (46%), of these 19/25 (76%) were homozygous. Small deletions (<200 kb) were found in 8/25 (32%) and the smallest deletion was <30 kb. The only gene affected in all deletions was CDKN2A. We were unable to demonstrate prognostic value of the deletion, however patients with deletion belonged more often (P = 0.06) to unfavorable biological category. Our results indicate that CDKN2A deletions <200 kb may not be detected by conventional methods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 32, Issue 8, August 2008, Pages 1228–1235
Journal: Leukemia Research - Volume 32, Issue 8, August 2008, Pages 1228–1235
نویسندگان
Anu Usvasalo, Suvi Savola, Riikka Räty, Kim Vettenranta, Arja Harila-Saari, Pirjo Koistinen, Eeva-Riitta Savolainen, Erkki Elonen, Ulla M. Saarinen-Pihkala, Sakari Knuutila,