کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2139322 1087900 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tailoring tyrosine kinase inhibitor therapy to tackle specific BCR-ABL1 mutant clones
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Tailoring tyrosine kinase inhibitor therapy to tackle specific BCR-ABL1 mutant clones
چکیده انگلیسی

Several tyrosine kinase inhibitors (TKIs) are currently under development for the treatment of patients with chronic myelogenous leukemia (CML) resistant or intolerant of imatinib therapy, including nilotinib, dasatinib, and bosutinib. The current paradigm of TKI therapy involves a sequential use of these compounds, with imatinib invariably used as frontline therapy followed by either dasatinib or nilotinib on an empiric basis. A more sensible approach to this sequence is the selection of the TKI best suited to overcome the resistance conferred by BCR-ABL1 mutations detected at each time-point. As more TKIs are becoming available, the management of patients with CML will require degree of “finesse” to better match each patient with the best TKI available. This match is best made based on available in vitro data regarding the activity of each agent against each specific mutation. The case herein reported supports such strategy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 32, Issue 8, August 2008, Pages 1313–1316
نویسندگان
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