کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2139348 | 1087901 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia](/preview/png/2139348.png)
چکیده انگلیسی
Methylation profile was analyzed in 10 childhood acute lymphoblastic leukemia (ALL) and nine adult ALL cases. Four genes (p15, p16, RARβ, FHIT) had methylation in both diseases, four genes (p14, Rb, MLH1, DAPK) showed no methylation in both diseases, and the two genes (APC, RIZ) demonstrated methylation only in adult ALL. Methylation of the RARβ was more frequent in adult ALL than that in childhood ALL (p = 0.01). The number of patients with methylation of multiple genes was higher in adult ALL than that in childhood ALL (p = 0.006). Moreover, overall frequency of methylation was higher in adult ALL than that in childhood ALL (p = 0.01).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 30, Issue 1, January 2006, Pages 98–102
Journal: Leukemia Research - Volume 30, Issue 1, January 2006, Pages 98–102
نویسندگان
Yang Yang, Seisho Takeuchi, Wolf K. Hofmann, Takayuki Ikezoe, Jacques J.M. van Dongen, Tomasz Szczepański, Claus R. Bartram, Norihide Yoshino, Hirokuni Taguchi, H. Phillip Koeffler,