کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2139413 1087903 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
BCR-ABL mutant kinetics in CML patients treated with dasatinib
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
BCR-ABL mutant kinetics in CML patients treated with dasatinib
چکیده انگلیسی

Dasatinib is efficient in vitro against most of CML cells harboring ABL kinase domain mutations and induces high rates of response in imatinib-resistant CML patients. Here, we monitored the mutated BCR-ABL transcripts during the follow-up of 12 CML patients treated with dasatinib. We identified four groups of patients based on their sensitivity to dasatinib. Clinical responses were correlated to the in vitro sensitivity of BCR-ABL mutants to dasatinib, however, some discrepancies were observed in a subfraction of CML patients, suggesting subtle differences between in vitro observations and clinical entities and/or the onset of other mechanisms responsible for dasatinib resistance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 31, Issue 6, June 2007, Pages 865–868
نویسندگان
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