کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2139484 | 1087906 | 2007 | 11 صفحه PDF | دانلود رایگان |
Acute myelogenous leukaemia (AML) blasts transmigrate in response to SDF-1α. AMD3100, a novel bicyclam molecule which inhibits stromal-derived factor (SDF)-1α/CXCR4 interactions, inhibited the transmigration of AML blasts and inhibited outgrowth of leukemia colony forming units. AMD3100 did not abrogate stroma-mediated protection from cytarabine-mediated apoptosis, except in the case of one promyelocytic leukemic sample tested, and it did not influence adhesion of blasts to endothelial monolayers. When AML blasts were pretreated with AMD3100, the positive effects of SDF-1α on NOD/SCID engraftment were diminished. This work confirms that AML is influenced by the SDF-1α/CXCR4 axis and demonstrates that disruption of this axis by the bicyclam AMD3100 can influence AML microenvironmental interactions.
Journal: Leukemia Research - Volume 31, Issue 11, November 2007, Pages 1553–1563