کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2139515 | 1087907 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
VH3–48 and VH3–53, as well as VH3–21, gene rearrangements define unique subgroups in CLL and are associated with biased lambda light chain restriction, homologous LCDR3 sequences and poor prognosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study determined IgVH gene usage in 228 chronic lymphocytic leukaemia patients to investigate associations between gene usage and other biological or clinical characteristics. VH3–48 [N = 8] and VH3–53 [N = 4] gene rearrangements showed biased λ light chain restriction and were predominantly found in female patients with short lymphocyte doubling time but without adverse prognosis cytogenetics. Overuse of VL3–21(Vλ2–14) gene and highly homologous LCDR3 sequences were found in VH3–48 patients. VH3–21 gene usage [N = 18, 7.9%] was associated with poor prognosis, overuse of VL3–21(Vλ2–14) gene and highly homologous heavy- and light-chain CDR3 sequences, but was not associated with poor prognosis chromosomal aberrations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 31, Issue 2, February 2007, Pages 231–234
Journal: Leukemia Research - Volume 31, Issue 2, February 2007, Pages 231–234
نویسندگان
Christine Matthews, Mark A. Catherwood, T.C.M. ‘Curly’ Morris, H. Denis Alexander,