کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2139520 | 1087907 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low-dose thalidomide in combination with oral fludarabine and cyclophosphamide is ineffective in heavily pre-treated patients with chronic lymphocytic leukemia
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Elevated levels of TNF-α have been associated with progressive disease in patients with chronic lymphocytic leukemia (CLL). Thalidomide has been shown to inhibit production of TNF-α.We investigated the effects of thalidomide on clinical outcome and TNF-α serum levels in five pre-treated CLL patients. The schedule consisted on daily thalidomide (Thal), oral fludarabine (Flu) and oral cyclophosphamide (CTX). Median duration of treatment was 60 days; four patients stopped treatment for disease progression and one patient for neurological toxicity. Serum TNF-α levels did not show any decrease during treatment. Low-dose thalidomide is not effective in CLL patients with refractory disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 31, Issue 2, February 2007, Pages 253–256
Journal: Leukemia Research - Volume 31, Issue 2, February 2007, Pages 253–256
نویسندگان
Luca Laurenti, Paola Piccioni, Michela Tarnani, Laura De Padua, Mariagrazia Garzia, Dimiter G. Efremov, Nicola Piccirillo, Patrizia Chiusolo, Simona Sica, Giuseppe Leone,